Clinical research progress of neonatal bacterial meningitis
10.3760/cma.j.issn.2095-428X.2014.22.022
- VernacularTitle:新生儿细菌性脑膜炎的临床研究进展
- Author:
Qiaozhen WEI
;
Haisheng LYU
- Publication Type:Journal Article
- Keywords:
Bacterial meningitis;
Glucocorticoid;
Sequela;
Infant,newborn
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(22):1756-1758
- CountryChina
- Language:Chinese
-
Abstract:
Neonatal bacterial meningitis may lead to severe neurological sequelaes,with a high mortality rate.It shows different etiology characteristics in different regions and different days of age.The lack of specific clinical manifestations of the disease,easily lead to delays in diagnosis and treatment.Diagnosis needs to realize cerebrospinal fluid (CSF) culture and biochemical parameters by lumbar puncture,however,the rate of positive in CSF culture is extremely low,and the sensitivity in biochemical parameters in the early days and after treatment with antibiotics may be decreased.The reverse transcription-PCR technique may improve the early diagnosis of specificity and sensitivity,but which is expensive and restricted by technical conditions,therefore,clinicians should be alert to the suspicious children and to check in time even repeated lumbar puncture.The third generation of cephalosporins antibiotics are the choices for gram-negative bacilli,gram-positive coccus preferred vancomycin,hormone application is still not advocate.Because of greater incidence of neurological complications of bacterial meningitis in neonates,head imaging examination timely in treatment process is an important means of assessing prognosis.
