Significance of cerebrospinal fluid matrix metalloproteinase-9, interleukin-6, and tumor necrosis factor-alpha protein in children with viral encephalitis
10.3760/cma.j.issn.2095-428X.2014.22.012
- VernacularTitle:病毒性脑炎患儿脑脊液基质金属蛋白酶-9、白细胞介素-6、肿瘤坏死因子-α变化的意义
- Author:
Donglin SHEN
;
Yuanyuan DAI
;
Jiao CHEN
;
Ming LU
;
Mingxia SUN
- Publication Type:Journal Article
- Keywords:
Viral encephalitis;
Structural proteins 100B;
Matrix metalloproteinase-9;
Interleukin-6;
Tumor necrosis factor-alpha;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2014;29(22):1721-1723
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of changes of matrix metalloproteinase-9 (MMP-9),interleukin-6 (IL-6),and tumor necrosis factor-alpha (TNF-oα) protein level in the cerebrospinal fluid (CSF) of children with viral encephalitis (VE).Methods The concentration of neuron-specific enolase (NSE),structural proteins 100B (S100B),and MMP-9,IL-6,TNF-α in the CSF of VE children were detected by an enzyme linked immunosorbent assay,and the correlations of them were analyzed.Results NSE,S100B,MMP-9,IL-6,TNF-α protein expression could be found significantly higher than those in the control group,and there were significant differences according to statistics expression trends(all P ＜0.05).The NSE protein expression was significantly positive related with S100B in the VE group (r =0.467,P =0.009),and the concentration was markedly negative related with the duration of viral encephalitis (r =-0.472,P =0.008).MMP-9,IL-6 protein expression were significantly positive related with NSE,S100B respectively (r =0.698,P =0.00 ; r =0.559,P =0.00 ; r =0.812,P =0.00 ; r =0.664,P =0.00).TNF-α protein expression was positive related with CSF S100B(r =0.363,P =0.049),but there was no correlation between TNF-α and NSE (r =0.245,P =0.193).Conclusions The neurons and the neuroglial cells are damaged in the viral encephalitis children.MMP-9,IL-6,TNF-α protein may participate in the pathological damage process of nerve cells in VE children in different degrees.
