Current treatment of acute myeloid leukemia by targeting leukemia stem cells
10.3760/cma.j.issn.1009-9921.2013.07.005
- VernacularTitle:急性髓系白血病的白血病干细胞靶向治疗现状
- Author:
Liru WANG
;
Ding TIAN
- Publication Type:Journal Article
- Keywords:
Leukemia,myeloid,acute;
Stem cell;
Therapy
- From:
Journal of Leukemia & Lymphoma
2013;22(7):395-398
- CountryChina
- Language:Chinese
-
Abstract:
Acute myeloid leukemia (AML) originates from rare leukemia stem cells (LSC).Because these chemotherapy-resistant LSC are thought to underlie disease relapse,effective therapeutic strategies specifically targeting these cells may be beneficial.With the increasing knowledge regarding the LSC,several major directions in targeted therapies with regard to LSC are being investigated.These include targeting cell surface molecules,signal pathways,and microenvironment of LSC.Since eliminating LSC-should provide an efficient,potentially curative treatment option for leukemia patients,this article reviews the recent progress of LSC targeting in AML therapy.
