Chronic inflammation in the promotion of lung carcinogenesis
10.3760/cma.j.issn.1673-422X.2014.12.009
- VernacularTitle:慢性炎症对肺癌发生的促进作用
- Author:
Ruixu YANG
;
Jiong DENG
- Publication Type:Journal Article
- Keywords:
Inflammation;
Lung neoplasm;
NF-kappa B
- From:
Journal of International Oncology
2014;41(12):906-909
- CountryChina
- Language:Chinese
-
Abstract:
Chronic inflammation is proved to play an important role in promoting carcinogenesis.Many factors in inflammatory microenvironment,such as inflammatory immune cells,pro-inflammatory cytokines,inflammatory mediators,and aberrantly activated transcription factors of pro-inflammatory pathway (NF-κB,STAT3),have been found to provide a microenvironment for lung neoplastic processes,and promote the lung carcinogenesis.On the other hand,many anti-inflammatory agents have been shown having inhibitory effects on lung tumorigenicity.With further understanding of the molecular links between inflammation and lung tumorigenesis,anti-inflammation would provide alternative strategies for prevention and therapy of lung cancer.
