Research advance on vasculogenic mimicry in glioma
10.3760/cma.j.issn.1673-422X.2014.12.008
- VernacularTitle:胶质瘤中血管生成拟态的研究进展
- Author:
Jun DENG
;
Yuhong GUO
;
Geng GUO
- Publication Type:Journal Article
- Keywords:
Glioma;
Vasculogenic mimicry
- From:
Journal of International Oncology
2014;41(12):902-905
- CountryChina
- Language:Chinese
-
Abstract:
Vasculogenic mimicry (VM) is a pattern of neoplasm cells,which achieve their blood supplements through deformation and simulating capillary channels.Cumulative studies show that the formation of VM in glioma have a close relation with the glioma stem cells.In addition,some molecules such as microRNA,epithelial cell kinase-A2,vascular endothelial cadherin,transforming growth factor-Jβ,vascular endothelial growth factor receptor-2 and galectin-1 play important roles in the forming process of vasculogenic mimicry.Recently,it is found that VM is associated with the poor prognosis of patients with glioma and anti angiogenesis drug efficacy.So the research on VM about the discovery,formation mechanism,prognostic impact and the clinical significance will provide an opportunity for diagnosis and therapy of glioma in early stage.
