Description and mechanism of cognitive impairment post-HSCT

VernacularTitle:造血干细胞移植术后患者认知功能损害的现状及其机制
Author: Xiaojian ZHU ; Ping ZOU
Publication Type:Journal Article
Keywords: Hematopoietic stem cell transplantation; Cognition disorders; Graft vs host disease; Microglia; Receptor,N-methyl-D-aspartic acid
From: Journal of Leukemia & Lymphoma 2013;22(6):339-341
CountryChina
Language:Chinese
Abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a highly successful treatment for hematological malignancies,severe congenital immunodeficiencies and some other diseases.Approximate 50 ％ of the disease-free survival patients suffered from long-lasting severe cognitive impairment after allo-HSCT.Pathological evidences showed parenchymal lymphocytic inflammation,microglia activation,and mild cerebral angiitis-like changes in allogeneic transplanted animals and patients' autopsy.Pay much importance attention to the pathological changes of central nervous system and its impact on cognitive function and take suitable measures would help the patients to achieve a state of complete physical mental and social well-being.