Roles of Hedgehog signaling in T cell differentiation and development
10.3760/cma.j.issn.1673-422X.2014.11.005
- VernacularTitle:Hedgehog信号通路对胸腺T细胞分化发育的影响
- Author:
Xiaobing FENG
;
Yuemin LI
;
Yang LI
- Publication Type:Journal Article
- Keywords:
T-lymphocytes;
Thymus gland;
Cell differentiation;
Hedgehog signaling pathway
- From:
Journal of International Oncology
2014;41(11):813-816
- CountryChina
- Language:Chinese
-
Abstract:
The production of mature functional T cells requires many signals from the thymus such as Wnt,Notch and Hedgehog,et al.The Hedgehog protein family signals for development,patterning and organogenesis of many tissues during mammalian embryogenesis.In recent years,more and more research groups focus their attention on it because of its relationship between tumors.Abnormal differentiation and development of T cells may cause various immunological diseases and tumors.Illuminating the roles of Hedgehog signaling in T cell differentiation and development can provide a theoretical guide in the treatment of tumor.
