Chemotherapy combined with infusion related HLA-mismatched hematopoietic stem cells for hematologic malignancies: a novel therapeutic strategy

VernacularTitle:化疗联合亲缘HLA不全相合造血干细胞输注治疗血液系统恶性疾病
Author: Li FU ; Tingting WANG ; Na WEI ; Dayong HUANG ; Jinli LIU ; Zhao WANG
Publication Type:Journal Article
Keywords: Hematopoietic stem cells transplantion; Hematologic neoplasms; Chimerism; Graft vs host disease; Antineoplastic combined chemotherapy protocols
From: Journal of Leukemia & Lymphoma 2013;22(6):379-382
CountryChina
Language:Chinese
Abstract: Objective To investigate the therapeutic outcomes of chemotherapy with infusion related HLA-mismatched hematopoietic stem cells for hematologic malignancies.Methods Therapy responses and hematopoietic recovery as well as complications of 9 patients were analyzed.Results In the 9 patients aged 29-67 years,four were acute myeloid leukemia,one was acute B lymphocytic leukemia,two were multiple myeloma,one was Hodgkin' s disease,one was diffuse large B cell lymphoma.The average of MNC was (3.12±1.29)×108/kg,CD34+ cells was (1.71±1.00) ×106/kg,and CD3+ cells was (2.13 ±0.99) ×108/kg.There was complete remission in four patients,partial remission in one,disease progression in four.Following up 2 to 14 months,four patients were in survival.No donor chimerism was detected and no graft-versus-host disease was observed in any patient.Conclusion Chemotherapy with infusion related HLA-mismatched hematopoietic stem cells for hematologic malignancies may provide a promising treatment method as a novel therapeutic strategy.