Roles of ADAM17 in tumor metastasis and its molecular mechanism
10.3760/cma.j.issn.1673-422X.2014.10.001
- VernacularTitle:ADAM17在肿瘤转移中的作用及相关分子机制
- Author:
Jun CAO
;
Zhiqiang LING
;
Minghua GE
- Publication Type:Journal Article
- Keywords:
Neoplasm metastasis;
Signal transduction;
Adisintegrin and metalloproteinase
- From:
Journal of International Oncology
2014;41(10):721-724
- CountryChina
- Language:Chinese
-
Abstract:
As an important member of the adisintegrin and metalloproteinase (ADAM) superfamily,ADAM17 can mediate a variety of membrane molecular hydrolysis off,such as adhesion molecules,cytokines,growth factors,etc,and play an important role in regulating tumor cell adhesion,apoptosis,metastasis and proliferation through the EGFR-PI3K-Akt pathway,Notch signaling pathway and other signaling pathways.The research of ADAM17 targeted drugs provides a new direction for cancer therapy.
