DDX43 gene and tumors
10.3760/cma.j.issn.1673-422X.2015.02.009
- VernacularTitle:DDX43基因与肿瘤
- Author:
Qin CHEN
;
Jiang LIN
;
Jun QIAN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Gene expression;
Methylation;
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
- From:
Journal of International Oncology
2015;42(2):115-117
- CountryChina
- Language:Chinese
-
Abstract:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 (DDX43) plays an important role in the malignant proliferation,drug resistance of tumor cells as well as neoplasm immunotherapy.The overexpression of DDX43 has been found in various solid tumors and some hematologic malignancies.The hypomethylation of DDX43 gene promoter is identified in chronic myeloid leukemia,acute myeloid leukemia and myelodysplastic syndrome,which is correlated with DDX43 overexpression and the prognosis of these diseases.
