Mechanism of Tbx3 gene in tumor progression
10.3760/cma.j.issn.1673-422X.2015.01.009
- VernacularTitle:Tbx3基因在肿瘤进展中的机制
- Author:
Zezhi SHAN
;
Xuebing YAN
;
Yuan TIAN
;
Zhiming JIN
- Publication Type:Journal Article
- Keywords:
Neoplastic stem cells;
Methylation;
Tbx3;
Epithelial-mesenchymal transition
- From:
Journal of International Oncology
2015;42(1):37-39
- CountryChina
- Language:Chinese
-
Abstract:
As a member of T-box family,Tbx3 (T-box3) is widely expressed in multiple organs and involves in the development of breast,limb,heart,eye,lung and pancreas during embryonic development stage.Moreover,Tbx3 plays an important role in maintaining the embryonic stem cells.Recent studies show that Tbx3 can work as a transcription factor to participate in the initiation and progression of tumor by epithelialmesenchymal transition,induction tumor stemness and methylation.A better understanding of Tbx3 will provide new insights into genetic diagnosis and targeted treatment of tumor.
