Roles of transforming growth factor-β1 in cancer stem cells
10.3760/cma.j.issn.1673-422X.2014.12.005
- VernacularTitle:转化生长因子-β1在肿瘤干细胞中的作用
- Author:
Yulei MA
;
Haiyuan LI
;
Chuan ZHOU
;
Fenghai ZHOU
;
Haidi LYU
;
Shiguang WANG
- Publication Type:Journal Article
- Keywords:
Transforming growth factor beta 1;
Neoplastic stem cells
- From:
Journal of International Oncology
2014;41(12):893-895
- CountryChina
- Language:Chinese
-
Abstract:
Tumor stem cells are responsible for metastasis and relapse of cancer.Transforming growth factor-β1 (TGF-β1) plays an important role in the proliferation and differentiation of tumor stem cells.In many cancers such as breast carcinoma,hepatocellular carcinoma,pancreatic carcinoma,lung carcinoma,glioma and gallbladder carcinoma,the epithelial-mesenchymal transition (EMT) induced by TGF-β1 can inhibit proliferation of cancer cell,enrich tumor stem cells and increase invasive capability and drug resistance of cancer.
