Influence of canonical Wnt signaling pathway on the occurrence and development of ovarian cancer
10.3760/cma.j.issn.1673-422X.2014.11.014
- VernacularTitle:经典Wnt信号通路对卵巢癌发生发展的影响
- Author:
Cuilian LIU
;
Cheng CUI
;
Lifei WANG
;
Shuwei HAO
- Publication Type:Journal Article
- Keywords:
Ovarian neoplasms;
Beta catenin;
Cadherins;
Signal transduction
- From:
Journal of International Oncology
2014;41(11):844-847
- CountryChina
- Language:Chinese
-
Abstract:
The canonical Wnt signaling pathway has been the hot spot in the signaling pathway studies which are related to ovary carcinogenesis in recent years,whose activation may induce the multiplication and self-renewal,survival and metastasis of ovarian cancer stem cells.The target gene mutations of key members in the canonical Wnt pathway and abnormal expresses of negative regulation molecules are closely associated with the occurrence and development of ovarian cancer.Deeply investigating the regulative mechanisms of canonical Wnt signaling pathway in ovarian cancer,and taking this as the therapeutic target to conduct the basic research and preclinical experiment may provide theoretical basis for treating better ovarian cancer patients in clinical practice.
