Neosensitization to Multiple Drugs Following Valproate-Induced Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome.
- Author:
Jae Min SONG
1
;
Young Eun JUNG
;
Joon Hyuk PARK
;
Moon Doo KIM
;
Min Seok CHEON
;
Chang In LEE
Author Information
- Publication Type:Case Report
- Keywords: DRESS; Neosensitization; Valproate; Amoxicillin; Olanzapine; Quetiapine
- MeSH: Amoxicillin; Anticonvulsants; Drug Hypersensitivity Syndrome*; Female; Fever; Humans; Quetiapine Fumarate; Skin; Valproic Acid
- From:Psychiatry Investigation 2017;14(4):518-520
- CountryRepublic of Korea
- Language:English
- Abstract: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is associated with severe skin eruptions, fever, hematological abnormalities, and multi-organ involvement. Although aromatic anticonvulsant drugs have been frequently associated with the manifestation of DRESS syndrome, its induction following treatment with nonaromatic anticonvulsants, such as valproate, has rarely been reported. Moreover, there are limited data regarding the development of neosensitization related to chemically unrelated drugs following an episode of DRESS syndrome. Here, a case of neosensitization to multiple drugs is described. The present case report describes a female patient who experienced neosensitization to amoxicillin, olanzapine, and quetiapine following the manifestation of DRESS syndrome induced by valproate.
