Relationship between gastrin and miRNA in promoting colorectal cancer cell proliferation
10.3760/cma.j.issn.1673-422X.2014.10.017
- VernacularTitle:胃泌素与微小RNA在促大肠癌细胞增殖中的关系
- Author:
Guang YANG
;
Jiading MAO
- Publication Type:Journal Article
- Keywords:
Gastrins;
MicroRNAs;
Colorectal neoplasms
- From:
Journal of International Oncology
2014;41(10):775-778
- CountryChina
- Language:Chinese
-
Abstract:
It has been demonstrated that the combination of abnomal expression of gastrin with its receptor can promote cell proliferation and inhibit apoptosis in colorectal neoplasms via signal transduction pathways,which is related with the abnormal expression of miRNA.Researches show that there are multiple intersections between the molecule mechanisms of miRNA and the signaling pathway of gastrin in promoting colorectal cancer cell proliferation.It may exist a gastrin-miRNA-target gene signaling transduction pathway.Knowing the mechanism of the signaling pathway and controlling the related factors will open another avenue for the gene targeted therapy of colorectal neoplasms.
