A Case Report of a 37-Year-Old Alzheimer's Disease Patient with Prominent Striatum Amyloid Retention.
- Author:
Yoo Hyun UM
1
;
Woo Hee CHOI
;
Won Sang JUNG
;
Young Ha PARK
;
Chang Uk LEE
;
Hyun Kook LIM
Author Information
- Publication Type:Case Report
- Keywords: Early onset Alzheimer's disease; Striatum; Amyloid retention
- MeSH: Adult*; Alzheimer Disease*; Amyloid*; Apraxias; Diagnostic Imaging; Humans; Ligands; Male
- From:Psychiatry Investigation 2017;14(4):521-524
- CountryRepublic of Korea
- Language:English
- Abstract: With recent advancement in amyloid imaging, diagnostic application of this new modality has become a great interest among researchers. New ligands, such as 18F- florbetaben, florbetapir and flutemetamol, have been discovered to overcome limitations of preexisting ligand Pittsburgh compound B. We report here a case of a 37-year-old male patient whose initial complaints comprised of gradual cognitive decline, apraxia, disorientation and sleep disturbances. 18F-Florbetaben amyloid imaging of the patient showed diffuse amyloid retention with prominent striatal uptake. This finding supports the clinical utility of amyloid imaging in diagnostic process of early-onset AD. Moreover, striatal dominant uptake pattern demonstrated in this patient include some meaningful clinical implications that warrant special attention among clinicians.
