Related factors analysis of relapsed refractory Hodgkin lymphoma

VernacularTitle:霍奇金淋巴瘤复发、难治的相关因素分析
Author: Wenli WAN ; Jing WANG ; Lei TIAN ; Wei ZHANG ; Qiaohua ZHANG ; Xiaoyan KE ; Shuling HOU
Publication Type:Journal Article
Keywords: Lymphoma,non-Hodgkin; Stem cell transplantation; Recurrence
From: Journal of Leukemia & Lymphoma 2013;22(5):294-297
CountryChina
Language:Chinese
Abstract: Objective To investigate the related factors of relapsed refractory Hodgkin lymphoma (HL),analysis treatment and adverse reactions.Methods Clinical features and treatment outcome of 62 HL patients were analyzed retrospectively.Results Of the 62 HL patients,12 patients(19.35 ％) were relapsed refractory HL.Pathologic type (P =0.026),lymph node area ≥ 3 (P =0.030) and large mass (P =0.006) were important factors for relapsed and refractory.The median overall survival time of relapsed refractory HL was 69.5 months (27-129 months).The 5 year overall survival (OS) rates in relapsed refractory HL and others were 66.7 ％ and 88.8 ％ respectively (P =0.117).The 5 year event-free survival (EFS) rates in relapsed refractory HL were 52.4 ％ and others 87.9 ％ respectively (P =0.006).Conclusion Pathologic type,lymph node area ≥3 and large mass are closely related with refractory refractory.HL.At the same time,recurrence in the short-term (＜ 1 year) is the independent prognostic factor for patients with relapsed refractory HL.