Effect of different doses of atorvastatin on early neurological deterioration and short-term outcomes in patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2014.11.004
- VernacularTitle:不同剂量阿托伐他汀对急性缺血性卒中患者早期神经功能恶化和短期转归的影响
- Author:
Nihong CHEN
;
Junshan ZHOU
;
Fuping JIANG
;
Yukai LIU
;
Zhonghua ZHANG
;
Yanyan SHI
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Hydroxymethylglutaryl-CoA Reductase Inhibitors;
Treatment Outcome;
Atorvastatin
- From:
International Journal of Cerebrovascular Diseases
2014;22(11):848-852
- CountryChina
- Language:Chinese
-
Abstract:
Objective To intestate the effect of different doses of atorvastatin on early neurological deterioration and short-term outcomes in patients with acute ischemic stroke.Methods The patients with acute ischemic stroke were enrolled prospectively.They were randomly assigned to either a standard therapy group (atorvastatin 20 mg/d) or an intensive treatment group (atorvastatin 40 mg/d).The primary outcomes were early neurological deterioration within 1 week of treatment and the good outcome of evaluation at 1 month after treatment (the modified Rankin Scale score 0-2); the secondary outcomes were the National Institutes of Health Stroke Scale (NIHSS) score and adverse events at 1 month.Results A total of 125 patients with acute ischemic stroke were enrolled,including 62 in the standard therapy group and 63 in the intensive treatment group.The incidence of early neurological deterioration at 1 week after treatment in the standard therapy group was significantly higher than that in the intensive treatment group (16.13％ vs.4.76％;x2=4.333,P=0.038); the proportion of good outcome in the standard therapy group was significantly lower than that in the intensive treatment group at 1 month after treatment (53.23％ vs.71.43％ ;x2 =4.413,P=0.036).During the treatment,no significant liver damage,muscle toxicity and other adverse events of causing atorvastatin reduction or withdrawal occurred in the patients of both groups.Conclusions Using high-dose atorvastatin in the acute phase of ischemic stroke may decrease the incidence of early neurological deterioration compared with the conventional dose,and improve short-term clinical outcomes.
