Clinical observation of intensive immunosuppression combined with umbilical cord blood support therapy in severe aplastic anemia complicated with infection

VernacularTitle:强烈免疫抑制联合脐血支持治疗重型再生障碍性贫血并发感染的临床观察
Author: Xiaochen SONG ; Fang ZHOU
Publication Type:Journal Article
Keywords: Anemia,aplastic; Immunosuppressive therapy; Umbilical cord blood; Infection
From: Journal of Leukemia & Lymphoma 2013;22(3):172-174
CountryChina
Language:Chinese
Abstract: Objective To study the clinical characteristics and therapeutic effect of the combination of intensive immunosuppression therapy with umbilical cord blood infusion in severe aplastic anemia (SAA) patients with infections.Methods A retrospective analysis of bacterial spectrum and treatment effect was performed for infections occurred in 27 SAA-Ⅰ patients who received antithymocyte globulin (ATG),cyclophosphamide (Cy) and cyclosporine A (CsA) followed by umbilical cord blood infusion.Results The prevalence of infections in 27 SAA-Ⅰ patients was 48.1％,among which 70 ％ were infected with bacteria (mostly gram-negative bacilli) and 30 ％ with fungal infection.Upper respiratory tract was the most common site,followed by the blood and lungs.The primary infections occurred at the median time of 9.5 d (-2-10 d)after the immunosuppressive therapy,and the initial infections of ANC were ＜ 0.2 ×109/L.Conclusion Combination of intensive immunosuppression and umbilical cord blood infusion is proven effective in treating SAA-Ⅰ.As a result,infection rate is low and can be controlled with sensitive antibiotics.