Study on correlation between brain natriuretic peptide and anthracyclin-induced cardiac toxicity in patients with lymphoma
10.3760/cma.j.issn.1009-9921.2013.03.013
- VernacularTitle:淋巴瘤患者血浆脑钠肽与蒽环类药物心脏毒性的相关性研究
- Author:
Haitao XU
;
Fusheng YAO
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide,brain;
Anthracyclines;
Cardiotoxicity;
Echocardiography
- From:
Journal of Leukemia & Lymphoma
2013;22(3):169-171
- CountryChina
- Language:Chinese
-
Abstract:
anthracycline-induced cardiotoxicity in patients with lymphoma.Methods Thirty-two adult patients with nonHodgkin' s lymphoma who received chemotherapy including anthracyclin were studied.After anthracyclin reached the cumulative doses of 200 and 400 mg/m-2,the changes in plasma BNP and echocardiography indices were investigated.Results After the cumulative anthracyclin reached doses of 200 and 400 mg/m2,serum BNP were respectively (292±7) ng/ml and (387±4) ng/ml,and were significantly increased when compared to the untreated (134±6) ng/ml (P ＜ 0.05).The parameter of diastolic functions ratio of peak early to peak late low velocity (E/A ratio)were 1.14±0.37 and 0.90±0.06,both showing significant decreases compared to the control (1.33±0.27) (P ＜ 0.05).In contrast,systolic function parameters left ventricular ejection fraction (EF) and fractional shortening (FS) remained unchanged (P ＞ 0.05).After the cumulative anthracyclin reached 200 and 400 mg/m2,significant negative correlations were observed between the plasma BNP and the E/A ratio (r =-0.689,P=0.042; r=-0.557,P =0.006),but no associations between EF and FS were found (P ＞ 0.05).Conclusion Plasma BNP concentration appears to be a sensitive parameter for the early assessment of anthracycline-induced cardiotoxicity.
