Poly (ADP-ribose) polymerase-1 and ischemic brain injury
10.3760/cma.j.issn.1673-4165.2014.12.012
- VernacularTitle:聚(ADP-核糖)聚合酶-1与缺血性脑损伤
- Author:
Xiaoxi LI
;
Yanting CHEN
;
Yun XU
- Publication Type:Journal Article
- Keywords:
Poly(ADP-ribose) Polymerases;
Brain Ischemia;
Cell Death;
Inflammation;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2014;22(12):946-949
- CountryChina
- Language:Chinese
-
Abstract:
Poly (ADP-ribose) polymerase-1 (PARP-1) is a ribozyme that widely exists in the cukaryotic cells.It plays important roles in the maintenance of genomic stability and the regulation of gene transcription and other physiological processes.PARP-1 is overactivated after ischemic brain injury,and PARP-1 gene knockout mice or PARP-1 inhibitor can reduce brain injury in a variety of models of cerebral ischemia.Therefore,PARP-1 plays important roles in the pathophysiologic processes of ischemic brain injury.The investigation of the effect of PARP-1 in cerebral ischemia contributes to further understanding the pathophysiologic mechanism of stroke and finding a new therapeutic target.
