Clinical analysis of chemotheray-induced lung injury in 26 patients with malignant hematological diseases
10.3760/cma.j.issn.1009-9921.2013.02.010
- VernacularTitle:恶性血液肿瘤患者化疗后肺损伤26例临床分析
- Author:
Wei ZHAO
;
Fei DONG
;
Jing WANG
;
Xiaoyan KE
- Publication Type:Journal Article
- Keywords:
Lymphoma;
Leukemia;
Chemotheray-induced lung injury
- From:
Journal of Leukemia & Lymphoma
2013;22(2):94-97
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the clinical characteristics,treatments and prognosis of the chemotheray-induced lung injury in malignant hematological diseases patients.Methods 26 malignant hematological diseasespatients with chemotheray-induced lung injury were collected.The clinical characteristics,chemotherapy regimen,treatments and prognosis of the patiants were retrospectively analyzed.Results Among 26 patients,10 patients were male and 16 patients were famale.The dignosis were nonHodgkin's lymphoma (16 cases),leukemia (9 cases) and multiple myeloma (1 case).The chemotherapy regimens inducing lung injure probably were R-CHOP,R-BEACOP and BEACOP in lymphoma,while they were HA,AA,DA and IA in leukemia.The symptoms of lung injury in these patients were fever,cough,hemoptysis,dyspnea,fatigue,or asymptomatic radiological examination revealed.Pulmonary diffuse infiltration and shadows were showed in CT scan.21 cases were cured by hormone therapy,5 cases died of lung injury,2 cases died of tumor recurrence after lung injury cured.There was no effect on the quality of life in most cured patients.Conclusion The lung injury induced by chemotherapy has no specific clinical characteristics and diagnostic criteria,and it could progress rapidly to cause death.But early dignosis and early hormonal treatment can obtain good therapeutic effect.The occurrence regularity and clinical characteristics should be studied furtherly.
