Treating exploration and prospect on myelodysplastic syndromes

VernacularTitle:骨髓增生异常综合征的治疗探索与展望
Author: Rou MA
Publication Type:Journal Article
Keywords: Myelodysplastic syndromes; Qinghuang powder; Demethylation
From: Journal of Leukemia & Lymphoma 2013;22(2):85-87
CountryChina
Language:Chinese
Abstract: The myelodysplastic syndromes (MDS) are a group of clonal heterogeneous disorders of hematopoietic/progenitor.There are differences between Chinese and Western on cytogenetic typing of MDS.The arsenic-containing Chinese herbal formula Qinghuang powder is exact effective in the treatment of MDS.The clinical effect mechanism research indicated that treatment with arsenic-containing Chinese herbal formula had no effect on karyotype status,but resulted in a significant genome wide demethylation.The effective arsenic-concentration in blood is (19.39±10.36) μg/L,which is obviously lower than that in treating APL.