Advances in animal models of vascular cognitive impairment
10.3760/cma.j.issn.1673-4165.2014.09.007
- VernacularTitle:血管性认知损害动物模型研究进展
- Author:
Zhiqiang WANG
;
Qingsong WANG
- Publication Type:Journal Article
- Keywords:
Cognition Disorders;
Dementia,Vascular;
Disease Models,Animal;
Brain Ischemia
- From:
International Journal of Cerebrovascular Diseases
2014;22(9):671-676
- CountryChina
- Language:Chinese
-
Abstract:
With the thorough research on cognitive impairment in old age,vascular cognitive inpairment (VCI) has become a hot research field of neuroscience in recent years.Yet,the VCI-related pathogenic mechanism currently remains unknown.Therefore,the reliable and stable animal models are needed to reveal the pathogenesis and pathophysiologic changes of VCI in order to provide a theoretical basis for early warning,diagnosis and treatment of VCI.The commonly used animal models now have their own advantages and disadvantages,the results have greater differences.This article reviews the commonly used VCI animal models,related cognitive behavior changes,and change characteristics of histopathology in recent years,and the reasonable animal models of VCI according to different research objectives are investigated preliminarily.
