Significance of combined measurement of immunophenotype and international staging system in multiple myeloma
10.3760/cma.j.issn.1009-9921.2013.01.019
- VernacularTitle:多发性骨髓瘤免疫标志联合国际分期系统分期对临床治疗及预后判断的意义
- Author:
Lanlan HE
;
Xiaobao XIE
;
Guoqiang QIU
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Immunophenotype;
Clinical staging system;
Survival time;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2013;22(1):57-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the immunophenotype characteristics,the clinical significance of CD28 and International staging system in multiple myeloma (MM).Methods BM aspirate samples from 49 newly diagnosed MM patients and 22 patients after treatment were assessed using 4 color flow cytometric analyses.These MM patients were classified according to International staging system and the consolidated risk staging system,and the survival rates and treatment efficiency of 2 staging system were compared.Results The higher stage,according to the international staging system,the lower treatment efficiency [the efficacy rates of Ⅰ,Ⅱ,Ⅲ stage were 83.3 ％ (4/6),38.5 ％ (5/13),38.5 ％ (5/13),36.5 ％ (19/52)](x2 =4.235,P =0.04),and the survival and progression-free survival time of high-risk group were significantly shortened (P ＜ 0.05).The rate of CD28 abnormal expression was no significant different between the initial and the treatment group [27 (55.1％),14 (63.4 ％)],also similar in the impact of survival and progression-free survival time (P ＞ 0.05).According to the consolidated risk staging system,the treatment efficiency,the survival and progression-free survival time of high-risk group were significantly shortened than the low ones (P =0.040).Conclusions The patients with higher ISS stage,abnormal expression of CD28,and high-risk group have poor prognosis.
