Correlation between paraoxonase 1 Q192R polymorphism and ischemic stroke in Chinese Han population

VernacularTitle:对氧磷酶1基因Q192R多态性与中国汉族人缺血性卒中的相关性
Author: Jing ZHOU ; Chengguo ZHANG ; Yukai WANG ; Yan SHAO ; Haiqun XIE ; Jinhuan CUI
Publication Type:Journal Article
Keywords: Stroke; Brain Ischemia; Atherosclerosis; PON1 Protein,Human; Polymorphism,Genetic; Risk Factors
From: International Journal of Cerebrovascular Diseases 2014;22(9):641-644
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation between large artery atherosclerotic stroke and paraoxonase 1 (PON1) Q192R polymorphism.Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the PON1 Q192R polymorphism of 120 patients with large artery atherosclerotic stroke (case group) and 117 healthy subjects (control group).Results There was significant difference in the genotype distribution of PON1 Q192R (x2 =18.727,P＜0.001) and the allele frequency distribution (x2 =16.427,P ＜0.001) between the case group and the control group.Multivariate logistic regression analysis showed that RR genotype was an independent risk factor for large artery atherosclerotic stroke (odds ratio 1.377,95％ confidence interval 1.032-2.185; P =0.026).Conclusions The allelic gene mutation rate of PON1 Q192R in patients with large artery atherosclerotic stroke was significantly higher than that in the healthy population.RR genotype is an independent risk factor for large artery atherosclerotic stroke.