Effect of Ipratropium bromide combined with atomization inhalation of budesonide on acute exacerbation of chronic obstructive pulmonary disease
10.3760/cma.j.issn.0254-9026.2015.07.009
- VernacularTitle:异丙托溴铵联合布地奈德呼吸机Y管雾化吸入治疗慢性阻塞性肺疾病患者急性加重期的研究
- Author:
Yuliang ZHAO
;
Guangke CAO
;
Zhihai LI
;
Yingjun SHI
;
Wang ZHU
;
Ge YANG
;
Fanying MENG
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Ipratropium;
Budesonide;
Ventilators,negative-pressure
- From:
Chinese Journal of Geriatrics
2015;34(7):726-727
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the clinical efffects off Ipratropium bromide combined with atomization inhalation of budesonide via a ventilator with a Y-shaped connector on acute exacerbation off chronic obstructive pulmonary disease (AECOPD).Methods A total off 62 AECOPD patients treated at our hospital from June 2013 to September 2014 were randomly divided into the experimental group (n=31,treated with ipratropium bromide combined with atomization inhalation of budesonide) and the control group (n =31,treated with the same amount of saline).Results The airway pressure of mechanical ventilation,the time of mechanical ventilation and the time of staying in the intensive care unit all showed significant differences between the experimental and control groups [(25.4±5.2) cmH2O vs.(38.1±3.4) cmH2O,(6.5±1.3) d vs.(6.8±1.4) d,(8.9±2.1) d vs.(9.5±1.5) d,t=10.934,0.960,1.108,respectively,P＜0.05 for all].The rate of tracheotomy was lower in the experimental group than in the control group (17/31 or 54.8％ vs.20/31 or 64.5％,x2 =0.603,P＜0.05).Conclusions Ipratropium bromide combined with budesonide inhalation under mechanical ventilation via a Y-shaped connector has ffavorable clinical effects on AECOPD.
