Clinical effects of Nicergoline on swallowing and cognitive impairments in stroke patients
10.3760/cma.j.issn.0254-9026.2015.06.013
- VernacularTitle:尼麦角林改善脑卒中患者吞咽和认知功能障碍的临床观察
- Author:
Ying LI
- Publication Type:Journal Article
- Keywords:
Stroke;
Cognition disorders;
Deglutition disorders;
Substance P
- From:
Chinese Journal of Geriatrics
2015;34(6):627-629
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Nicergoline on swallowing function,substance P level and cognitive function in stroke patients.Methods A total of 60 patients developing stroke within 1-3 months with swallowing and mild to moderate cognitive impairments were selected and randomly divided into Nicergoline group (n=30,patients taking Nicergoline 20 mg,tid,for 4 weeks) and control group (n=30,patients taking placebo for 4 weeks).The swallowing function was evaluated,change of serum P substance level and the improvement of cognitive function were observed after 4 weeks of treatment.Results The swallowing function was improved in Nicergoline group after 4 weeks of treatment as compared with pre-treatment [(7.15 ± 1.76) scores vs.(5.42±1.89) scores,t=3.669,P=0.001],while it had no significant difference in the control group before versus after treatment (t=0.115,P=0.909).The substance P level was increased in Nicergoline group after 4 weeks of treatment as compared with pre-treatment [(189.6 ± 41.3) ng/L vs.(112.3±38.5) ng/L,P＜0.01],and it was slightly increased in control group after treatment,but there was no significant difference (t=0.933,P=0.355).In Nicergoline group,MMSE and MoCA scores were higher after treatment than before treatment [(24.77±5.75) vs.(19.22±2.36),(18.53±5.42) vs.(14.02±3.52),t=4.891 and 3.822,both P=0.000],while they had no significant differences in control group before versus after treatment (both P＞0.05).Conclusions Nicergoline can improve swallowing function and reduce the incidence of aspiration pneumonitis as well as improve the cognitive function in stroke patients.
