Clinical significance of negative thyroglobulin and positive diagnostic whole body scan in patients with differentiated thyroid carcinoma who underwent thyroid remnant ablation
10.3760/cma.j.issn.2095-2848.2015.02.019
- VernacularTitle:分化型甲状腺癌患者清甲疗效评价中Tg阴性和诊断性全身显像阳性的临床意义
- Author:
Shuang HU
;
Ting JI
;
Bin LIU
;
Guohua SHEN
;
Anren KUANG
;
Rong TIAN
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Surgery,operative;
Radiotherapy;
Iodine radioisotopes;
Thyroglobulin
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2015;35(2):154-156
- CountryChina
- Language:Chinese
-
Abstract:
Diagnostic whole body scan (Dx-WBS) with 131I and serum Tg level are the main parameters to evaluate the effectiveness of thyroid remnant ablation in patients with DTC.Undetectable Tg and positive radioiodine uptake in the thyroid bed (Tg-/Dx-WBS+) may be found in some patients.However,the clinical significance is uncertain.A small amount of thyroidal remnant,a small DTC lesion,increased expression of NIS gene and autoimmune inflammation may all result in Tg-/Dx-WBS+.A wait-and-watch approach without rushing for high-dose radioiodine treatment might be a more reasonable approach for these patients.
