The effectiveness and influencing factors of 131I treatment for cervical lymph node metastases of papillary thyroid carcinoma
10.3760/cma.j.issn.2095-2848.2015.02.008
- VernacularTitle:131I治疗甲状腺乳头状癌颈部淋巴结转移的疗效观察及影响因素分析
- Author:
Xinyu WU
;
Yongju GAO
;
Wei YOU
;
Xinhui YAN
;
Jing CUI
;
Peng WANG
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Carcinoma,papillary;
Neoplasm metastasis;
Lymph nodes;
Radiotherapy;
Iodine radioisotopes
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2015;35(2):112-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effectiveness and influencing factors of 131I treatment for cervical lymph node metastases of papillary thyroid carcinoma (PTC).Methods Eighty-nine post-operative PTC patients (24 males,65 females,11-72 years) with cervical lymph nodes as the only site of metastasis (negative serum TgAb,1-4 times of 131I treatment) on 131I planar Rx-WBS or SPECT/CT were retrospectively reviewed.Results of 131I Rx-WBS or SPECT/CT,serum Tg levels under both TSH-suppressed and TSH-stimulated conditions were measured and recorded.CR and PR were recognized as effective therapy.x2 test and logistic regression analysis were used to analyze the data.Results The effective rate of 1-4 times of 131I treatment was 57.30％(51/89),73.03％(65/89),80.90％(72/89),83.15％(74/89),respectively (x2=18.792,P＜0.01).Logistic regression analysis suggested that therapeutic effectiveness was related to the size of metastatic lymph nodes and whether metastatic lymph nodes could be visualized on the post-ablative 131I Rx-WBS or SPECT/CT.Conclusions 131I treatment is an effective modality for PTC patients with cervical lymph nodes as the only site of metastasis.The cumulative effective rate increased within a limited times of treatment.The size of metastatic lymph nodes and whether metastatic lymph nodes could be visualized on the first post-ablative 131I Rx-WBS or SPECT/CT are the key factors for the therapeutic effectiveness.
