Correlation between 18F-FLT PET/CT imaging and microvessel density of tumor tissue in non-small cell lung cancer
10.3760/cma.j.issn.2095-2848.2015.01.001
- VernacularTitle:非小细胞肺癌18F-FLT PET/CT显像与肿瘤微血管密度的相关性
- Author:
Gengji WANG
;
Wenfeng YANG
;
Zheng FU
;
Jinming YU
;
Dianbin MU
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Tomography,emission-computed;
Tomography,X-ray computed;
Microvessel density;
Thymidine
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2015;35(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between 18F-FLT SUVmax and intratumoral microvessel density (MVD) in NSCLC patients.Methods From January 2008 to December 2010,68 patients (48males and 20 females; age ranging from 36 to 84 years) with NSCLC underwent 18F-FLT PET/CT followed by surgery within two weeks.Tumor proliferation was evaluated in terms of Ki67 labeling index (LI) with SP.MVD was determined using anti-CD31 mAb (CD31-MVD),anti-CD34 mAb (CD34-MVD) and anti-CD105 mAb (CD105-MVD) for each resected tumor.Linear correlation analysis was used to analyze data.Results The mean values of CD31-MVD,CD34-MVD and CD105-MVD were 159.6,166.1,and 38.0 per view field,respectively.Tumor SUVmax was 4.1±2.9,and Ki67 LI was (37.0± 14.5) ％,both of which had significantly correlations with CD105-MVD (r=0.550,0.633 ; both P＜0.05),but there was no significant relationship between SUVmax and CD31-MVD,CD34-MVD (r=0.228,0.235; both P＞0.05).Conclusion 18F-FLT PET/CT imaging has a positive relationship with CD105-MVD of NSCLC,and it could reflect the ability of tumor angiogenesis.
