Research progress on liver injury in acute pancreatitis
10.3760/cma.j.issn.1007-8118.2015.04.021
- VernacularTitle:急性胰腺炎肝损伤的研究进展
- Author:
Yanzhe XU
;
Youming DING
;
Bin WANG
;
Junhui XU
- Publication Type:Journal Article
- Keywords:
Acute pancreatitis;
Liver damage;
Cytokines;
Macrophage migration inhibitory factor (MIF);
Systemic inflammatory response syndrome
- From:
Chinese Journal of Hepatobiliary Surgery
2015;21(4):284-288
- CountryChina
- Language:Chinese
-
Abstract:
Considerable clinical and experimental evidence supports that liver injury in acute pancreatitis (AP) is a sign for the potential progression to systemic inflammatory reaction.The Kupffer cells,various cytokines and macrophage migration inhibitory factor (MIF) play important roles in the pathogenesis of AP associated liver injury.However,the specific molecular mechanism of the liver damage remains uncertain.Therefore,efforts should be made to clarify the regulatory mechanism and related cell signaling disorders of liver injury in AP,which could not only identify novel therapeutic targets,but also provide new insight into improving the clinical treatment.Here our review discusses the recent research progress on the etiology,pathology and diagnosis and treatments of liver injury in AP.
