Expression and clinical significance in pancreatic cancer of transcriptional intermediary factor 1β

VernacularTitle:转录中介因子1β在胰腺癌中的表达及临床意义
Author: Chao YU ; Jianxin JIANG ; Ling CHEN ; Chengyi SUN
Publication Type:Journal Article
Keywords: TIF1β; Pancreatic cancer; Tissue microarray; Immunohistochemistry
From: Chinese Journal of Hepatobiliary Surgery 2015;21(1):14-17
CountryChina
Language:Chinese
Abstract: Objective To investigate transcription intermediary factor 1β (TIF1β) expression in paracancerous pancreatic tissue and pancreatic tumor tissue by using tissue microarray.The relationship between TIF1β expression and clinicopathological factors in patients with pancreatic cancer was discussed.Method Tissuc microarray and immunohistochemical assay were utilized to detect expression of TIF1β protein in pancreatic cancer tissues and the corresponding non-tumor tissues from 91 cases.Results TIF1β protein were present in pancreatic cancer tissues as well as corresponding non-tumor tissues with varying degrees of expression,and was located in the nucleus.TIF1β expression in pancreatic cancer tissue was significantly higher than that of adjacent tissues (P ＜ 0.05).And it was noted that there was close correlations between TIF1β expression and clinical pathological staging,lymph node metastasis and TNM grading (P ＜ 0.05).Conclusions TIF1β is highly expressed in pancreatic cancer,clinically correlated with pathological staging,lymph node metastasis and TNM grading.TIF1β may play an important role in development of pancreatic cancer.