Elderly patients with hepatocellular carcinoma treated with transcatheter arterial chemoembolization with low doses of oxaliplatin
10.3760/cma.j.issn.1007-8118.2015.06.011
- VernacularTitle:低剂量奥沙利铂在老年原发性肝癌肝动脉化疗栓塞术中的应用
- Author:
Jupeng YANG
;
Jingyu LIU
;
Jijin YANG
;
Xue JIANG
;
Xu JIANG
;
Weixing WANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Transcatheter arterial chemoembolization;
Oxaliplatin;
Drug dosage
- From:
Chinese Journal of Hepatobiliary Surgery
2015;21(6):401-404
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of transcatheter arterial chemoembolization (TACE) using low doses of oxaliplatin in elderly patients with hepatocellular carcinoma.Methods A retrospective study was conducted in the Department of Interventional Radiology,Changhai Hospital from September 2009 to September 2011.Fifty-eight patients were divided into two groups according to the doses of oxaliplatin used in TACE as group 1 (40 mg/m2) and group 2 (80 mg/m2).The clinical data were collected and analyzed using SPSS 19.Results When compared with group 2,patiems in group 1 showed less postoperative nausea and vomiting (22.6％ vs.66.7％;x2 =11.43;P ＜0.05),lower pain scores (29.3％ vs.77.8％;x2 =13.73;P ＜ 0.05),and less decrease in leukocyte numbers (7.98 ± 1.04 × 199/L vs.3.98 ±1.66 × 199/L;t =8.27;P ＜ 0.05),and better liver function as measured by ALT [(44.1 ± 23.8) U/L vs.(79.4 ±24.7)U/L;t =-5.54;P ＜0.05].The two groups showed no significant differences at one year and three years on follow up with overall survival rates of 67.7％ vs.63.0％,30.7％ vs.22.2％,respectively,P ＞ 0.05.Conclusion Elderly HCC patients treated with TACE using low doses of oxaliplatin had milder side effects of chemotherapy and better overall survival.
