Association of single nucleotide polymorphism (SNP) in micro RNA-122 with genetic predisposition and early recurrence after resection for hepatocellular carcinoma

VernacularTitle:microRNA-122的单核苷酸多态性与肝癌易感性和术后复发的关系
Author: Zheng ZHOU ; Shuiyuan HUANG ; Daya LUO ; Weifeng ZHU ; Shufang WAN
Publication Type:Journal Article
Keywords: Hepatocellular carcinoma; microRNA-122; Single nucleotide polymorphism; Genetic predisposition; Recurrence
From: Chinese Journal of Hepatobiliary Surgery 2014;20(11):786-789
CountryChina
Language:Chinese
Abstract: Objective To investigate the association of single nucleotide polymorphism (SNP) in micro RNA-122 (miRNA-122) with genetic predisposition and early recurrence after resection for hepatocellular carcinoma(HCC).Methods This is a case-control study involving 173 HCC patients.DNA were exacted from cancer tissues embedded in paraffin and were amplified by PCR.The study aimed to explore SNP in gene sequence of miRNA-122 (357 base pair including extron.The outcomes of genetic predisposition were analyzed with early recurrence after resection for HCC.Results Only rs17669 was found in miRNA-122.The genetype frequence of C/C,T/T and C/T at rs17669 gene locus were 7(4.0％),110(63.6％)and 56(32.4％),respectively.When compared to T/T genetype,C/C genetype was a protective factor of risk of HCC (OR =0.213,95％ CI:0.062-0.732).Genetypes had no relationship with early recurrence after resection.Conclusion For HCC recurrence,rs17669 may be associated with genetic predisposition of HCC in Hans in Jiangxi infected with HBV.