Clinical study of bone marrow-sparing intensity-modulated radiation therapy for postoperative cervical cancer
10.3760/cma.j.issn.0254-5098.2015.06.009
- VernacularTitle:宫颈癌术后限定骨髓剂量盆腔调强放疗的临床研究
- Author:
Qin ZHANG
;
Han WANG
- Publication Type:Journal Article
- Keywords:
Cervical cancer;
Bone marrow-sparing;
Intensity-modulated radiation therapy;
Toxicity reaction
- From:
Chinese Journal of Radiological Medicine and Protection
2015;35(6):441-444
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effects and toxicities of bone marrow-sparing intensity-modulated radiation therapy (BMS-IMRT) for postoperative cervical cancer.Methods From January 2011 to June 2012,totally 70 postoperative patients with cervical cancer were divided into BMS-IMRT group with 34 cases and IMRT group with 36 cases randomly.External whole pelvic intensitymodulated irradiation combined with chemotherapy was carried out for all patients.The planning target volume received a dose of 45 Gy/25 fractions in all patients.Delineation of the pelvis and limitation dose were carried out in BMS-IMRT group:the pelvis V30 ≤ 50％.All cases received chemotherapy with cisplatin (40 mg/m2) once a week concurrently with radiotherapy.Results Treatment was completed in 67 patients,as the other 3 patients stopped chemotherapy because of myelosuppression.There was no statistically significant differences between two groups for the 2-year local control survival(LCS)and overall survival(OS),alimentary tract toxicity and urinary toxicity.IMRT group had more serious hematologic toxicity than BMS-IMRT group,with statistically significant difference (x2 =14.355,P ＜ 0.05).Conclusions The postoperative cervical cancer patients with poor prognostic factors who undergo concurrent chemoradiotherapy,IMRT group has more serious hematologic toxicity than BMS-IMRT group.The short-term effect and other toxicities reaction are similar between two groups.
