Expression of miRNAs in peripheral blood plasma of the residents surrounding hot springs with radon

VernacularTitle:某氡温泉周边居民外周血血浆中miRNAs的表达
Author: Chunxu LIU ; Mei TIAN ; Yan PAN ; Gang GAO ; Jianxiang LIU
Publication Type:Journal Article
Keywords: Hot springs with radon; Plasma; miRNAs
From: Chinese Journal of Radiological Medicine and Protection 2015;35(3):187-190
CountryChina
Language:Chinese
Abstract: Objective To investigate the expressions of miR-16,miR-106b,miR-449a,miR-34a and let-7g in peripheral blood plasma of the residents surrounding hot springs with radon in Hebei province.Methods A total of 41 randomly selected residents surrounding hot springs with radon were considered as the radon group,and 46 residents with same living habit but without contact with hot springs were considered as control.The miRNAs in the peripheral blood plasma of these two groups were detected with qRT-PCR.Results The levels of miR-16,miR-106b,miR-449a and let-7g in the radon group were significantly higher than those in control group (Z=-2.278,-3.835,-2.719,-2.721,P＜0.05).Alterations of these miRNAs were associated with radon exposure (t =2.154,3.711,2.319,2.015,P ＜ 0.05) but had no relationship with age,sex,smoking and drinking factors.No significant difference was observed in the plasma levels of miR-34a between the two groups.Conclusions miR-16,miR-106b,miR-449a and let-7g could be applied as potential biomarkers for radon exposure.