The associatio n between C677T polymorphism of methlenetetrahydrofolate reductase gene and susceptibility to hyperuricemia and gout: a meta-analysis
10.3760/cma.j.issn.1007-7480.2015.04.003
- VernacularTitle:亚甲基四氢叶酸还原酶基因C677T位点单核苷酸多态性与高尿酸血症及痛风易感性的Meta分析
- Author:
Cailiang SHEN
;
Yinhe CHEN
;
Xiaomin LIU
- Publication Type:Journal Article
- Keywords:
Hyperuricemia;
Gout;
Methylenetetrahydrofolate reductase;
Polymorphism,single nucleotide;
Meta analysis
- From:
Chinese Journal of Rheumatology
2015;19(4):224-232
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and susceptibility to hyperuricemia and gout.Methods The case-control studies from Chinese Biomedical Database,Chinese National Knowledge Infrastructure,Wanfang,Weipu,PubMed,Cochrane Library,OvidSP,Wiley Online Library,EBSCO,Elsevier Science Direct,Springer Link and Google scholar databases for the association of C677T polymorphism of MTHFR gene with hyperuricemia and gout.The pooled odds ratios (OR) with 95％ confidence intervals (CI) were appropriately derived from randomeffects or fixed-effects models to assess the association strength by RevMan 5.3 and Stata 12.0 software.Results Ten references enrolled 1 899 hyperuricemia patients and 5 403 controls,and 3 references enrolled 209 gout patients and 194 controls in total.The meta analysis showed that carriers of genotype CC [OR=0.42,95％CI (0.29,0.63),P＜0.01] and allele C [OR=0.54,95％CI (0.42,0.71),P＜0.01] had lower risk of hyperuricemia;genotype TT [OR=1.55,95％CI (1.32,1.83),P＜0.01] and allele T [OR=1.84,95％CI (1.38,2.45),P＜0.01] had higher risk of hyperuricemia,carriers of genotype CC [OR=0.32,95％CI (0.15,0.68),P=0.003] and allele C [OR=0.35,95％CI (0.17,0.70),P=0.003] hadlower risk of gout;genotype TT [OR=2.92,95％CI (1.74,4.92),P＜0.01] allele T [OR=2.69,95％CI(1.50,4.84),P=0.0009] had higher risk of gout.Conclusion The meta analysis reveals that C677T polymorphism of MTHFR gene is associated with the susceptibility to hyperuricemia and gout.
