Serum level of B cell activating factor correlates with disease activity in dermatomyositis
10.3760/cma.j.issn.1007-7480.2014.11.006
- VernacularTitle:皮肌炎患者血清B细胞活化因子水平与疾病活动度相关性研究
- Author:
Qinglin PENG
;
Xuezhi ZHANG
;
Yan WANG
;
Xin LU
;
Guochun WANG
- Publication Type:Journal Article
- Keywords:
Dermatomyositis;
B cell activating factor;
Lung disease,interstitial
- From:
Chinese Journal of Rheumatology
2014;18(11):743-746
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum levels of B cell activating factor (BAFF) and disease activity in the patients with dermatomyositis (DM).Methods Serum BAFF levels of 61 patients with DM and 25 matched healthy controls were measured by ELISA.The results of the two groups were compared using unpaired Mann-Whitney U test and the relevance was analyzed using Spearman correlation analysis.Results Serum levels of BAFF in DM patients were significantly higher compared to healthy controls [(274 7±264 6) pg/ml 与 (832±170) pg/ml,Z=-5.492,P＜0.01].A cross-sectional assessment revealed that serum BAFF levels were positively correlated with global disease activity (r=0.501,P＜0.001),muscle disease activity (r=0.303,P＜0.05),and cutaneous disease activity (r=0.467,P＜0.01).High serum BAFF levels were associated with increased incidence of interstitial lung disease (x2=17.238,P＜0.01).The longitudinal study showed modest correlations between serum BAFF levels and global disease activity (r=0.658,P＜0.01),muscle disease activity (r=0.307,P＜0.05),as well as cutaneous disease activity (r=0.565,P＜0.01).Conclusion Serum levels of BAFF correlate with disease activity in DM patients.The results of this study suggest that BAFF is a serological biomarker for DM disease activity.
