Effect of antibrain-antibody on blood-brain barrier and cerebral edema after traumatic brain injury
10.3760/cma.j.issn.1001-8050.2015.05.022
- VernacularTitle:抗脑抗体对创伤性脑损伤后血脑屏障和脑水肿的影响
- Author:
Hai SU
;
Yi ZHANG
;
Zulu SU
;
Hao CHEN
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Blood-brain barrier;
Cerebral edema;
Antibrain antibody
- From:
Chinese Journal of Trauma
2015;31(5):467-470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of antibrain-antibody (AB-Ab) in blood serum and the effect of AB-Ab on blood-brain barrier (BBB) and cerebral edema after the traumatic brain injury (TBI) in rabbits.Methods Forty-five New Zealand rabbits were randomly divided into control group (n =5),sham operation group (fenestration only without injury,n =15) and TBI group (severe lateral fluid percussion brain injury,n =15) according to the random number table.Sham and TBI animals were subdivided at postoperative 1,3,7 and 14 days.Level of AB-Ab,BBB permeability and brain water content were determined after operation.Results At each time point,serum AB-Ab level,BBB permeability and brain water content were higher in sham operation group and TBI group than in control group (P ＜0.05).At postoperative 3,7 and 14 days,serum AB-Ab level,BBB permeability and brain water content were higher in TBI group than in sham operation group (P ＜ 0.05).Conclusion Serum level of AB-Ab is significantly increased after TBI along with synchronous changes in BBB permeability and brain water content,indicating that AB-Ab may be associated with the increase of BBB permeability and brain edema.
