Clinical significance of the level of 8-iso-prostaglandin F2α, serum ferritin, superoxide dismutase in serum from children with severe mycoplasma pneumoniae pneumonia
10.3760/cma.j.issn.1008-6315.2014.09.030
- VernacularTitle:重症肺炎支原体肺炎患儿血清8异前列腺素F2α和血清铁蛋白以及超氧化物歧化酶水平变化及其临床意义
- Author:
Shanshan WANG
;
Changshan LIU
- Publication Type:Journal Article
- Keywords:
Severe mycoplasma pneumoniae pneumonia;
Oxidative stress;
Superoxide dismutase;
8-iso-prostaglandinF2α;
Serum ferritin;
Children
- From:
Clinical Medicine of China
2014;30(9):991-995
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change of 8-iso-prostaglandin F2α(8-iso-PGF2α),serum ferritin (SF) and superoxide dismutase(SOD) in serum from children with mycoplasma pneumoniae pneumonia(MPP) and severe mycoplasma pneumoniae pneumonia(SMPP),and investigate the correlation between the severity of lung injury induced by oxidative stress(OS) and the severity in children with SMPP.Methods Sixty cases with MPP,30 cases with SMPP and 20 health children were selected in our study.The level of 8-iso-PGF2α,SOD and SF in serum were detected.Results (1) There were no significant difference regarding of 8-iso-PGF2α levels between the MPP group and the healthy control group ((6.01 (13.14)) ng/L vs.4.33 (2.42)) ng/L,P ＞ 0.05).The 8-iso-PGF2α level in patient of the SMPP group was 24.20 (24.05)) ng/L,significantly higher than that in the healthy control group (P ＜ 0.01) and MPP group (P ＜ 0.01).(2) There were no significant difference between the MPP group μg/L] and the healthy control group in terms of SF level((80.91 (54.57) μg/L vs.(82.48 (70.60)) μg/L,P ＞ 0.05).The SF level in the SMPP group was 139.69 (120.98)) μg/L,significantly higher than that in the healthy control group(P ＜ 0.01) and MPP group(P ＜ 0.O1).(3) The level of SOD in the MPP group was 138.60(25.20)) kU/L,significantly higher than that in the healthy control group ((123.10(11.28)) kU/L; P ＜ 0.01).The level of SOD in the SMPP group was 94.43 (63.58)) kU/L,significantly lower than that in the healthy control group (P ＜ 0.05).And level of SOD in the MPP group was significantly higher than that in the SMPP group(P ＜ 0.01).Conclusion The severity of lung injury induce by OS was related with the severity of the children with SMPP.OS may be a important factor in patients with SMPP exacerbation of lung injury.
