Relationship between rs7903146-T/C polymorphism of TCF7L2 gene and gestational diabetes mellitus
10.3760/cma.j.issn.1008-1372.2015.01.018
- VernacularTitle:TCF7L2基因rs7903146多态性与妊娠期糖尿病的相关性
- Author:
Xiaolei ZHANG
;
Hongmei JI
- Publication Type:Journal Article
- Keywords:
Transcription factors;
Polymorphism,genetic;
Diabetes,gestational;
Polymerase chain reaction
- From:
Journal of Chinese Physician
2015;17(1):65-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between rs7903146-T/C polymorphism of transcription factor7-like 2 gene (TCF7L2) gene and gestational diabetes mellitus in Han population of Liaoning province.Methods The rs7903146-T/C polymorphism was detected in 115 healthy Han controls and 113 patients with gestational diabetes mellitus by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.Results There were three genotypes:CC,CT,and TT; and their frequencies in control group and patients were 95.65%/84.96%,4.35%/15.04%,and 0/0,respectively.The allele frequency T of rs7903146 in control group and the patients was 2.17% and 7.52%,respectively.There was statistical difference between two groups.Conclusions The rs7903146-T/C polymorphism of TCF7L2 might be associated with gestational diabetes mellitus in Liaoning Han population.