The inspection of sitagliptin to metabolic index and carotid artery IMT in metabolic syndrome patients with type 2 diabetes
10.3760/cma.j.issn.1008-1372.2015.01.016
- VernacularTitle:西格列汀对合并2型糖尿病的代谢综合征患者代谢指标及颈动脉内中膜厚度的影响
- Author:
Xianghua ZHANG
;
Xiaoyue WANG
;
Lu XU
;
Changqing LUO
;
Zihua LI
- Publication Type:Journal Article
- Keywords:
Hypoglycemic agents/therapeutic use;
Diabetes mellitus,type 2/complications;
Metabolic syndrome X/complications;
Diabetes mellitus,type 2/drug therapy;
Metabolic syndrome X/drug therapy;
Carotid arteries/pathology
- From:
Journal of Chinese Physician
2015;17(1):58-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of sitagliptin on blood glucose,blood pressure,blood lip and carotid artery intima media thickness (IMT) in metabolic syndrome patients with type 2 diabetes.Methods The clinical data were collected for 64 cases of inpatient and outpatient patients with metabolic syndrome with type 2 diabetes.Those patients included anti-diabetes native patients and patients only used the stable metformin dose.After signed off the informed consent form,those patients were randomized to the sitagliptin treatment group or original treatment group,and the metabolic index and carotid artery intima-media thickness were evaluated after 24 weeks treatment.Results The body mass index (BMI),waist circumference (WC),fasting plasma glucose (FPG),triglycerides (TG),high density lipoprotein cholesterol (HDL-C),systolic blood pressure (SBP),diastolic blood pressure (DBP),glycated hemoglobin a1c (HbA1c),and carotid artery IMT in two groups were comparable at baseline.After 12 weeks treatment,the FPG,TG,DBP,and HbA1c in the sitagliptin group were significantly better than original treatment group and the baseline,while there was no different between two groups in other index.After 24 weeks treatment,the FPG,TG,HDL-C,DBP,HbA1c,and carotid artery IMT in the sitagliptin group were significantly better than original treatment group and the baseline.Conclusions Sitagliptin presents the functions of lowering blood pressure,adjusting blood lipid,and protecting vascular endothelial in addition to lowering blood glucose.
