Clinical study on the association between global registry of acute coronary events score and N-terminal pro brain natriuretic peptide and heart function in patients with acute coronary syndromes
10.3760/cma.j.issn.1008-6315.2014.09.013
- VernacularTitle:急性冠状动脉综合征患者氨基末端B型利钠肽前体与全球急性冠状动脉事件注册评分及心功能关系的临床研究
- Author:
Zhijun ZHENG
;
Yuchuan SUN
;
Zhangfeng WANG
- Publication Type:Journal Article
- Keywords:
N-terminal pro brain natriuretic peptide;
Global registry of acute coronary events score;
Acute coronary syndromes;
Heart function
- From:
Clinical Medicine of China
2014;30(9):935-938
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between global registry of acute coronary events (GRACE) score,N-terminal pro brain natriuretic peptide (NT-proBNP) and heart function in patients with acute coronary syndromes(ACS).Methods One hundred and seventy-four ACS patients and 60 healthy persons were enrolled our study.Of ACS patients,96 cases were with unstable angina pectoris(UP) and 78 cases with acute myocardial infarction (AMI).The level of NT-proBNP,left ventricular ejection fraction (LVEF) and GRACE score were measured.Results The NT-pro BPN of patients with UP or AMI were 87.00(38.25,245.75) ng/L and 686.00 (169.00,1 852.75) ng/L,and GRACE score were (87.51 ± 17.69) and (134.74 ± 23.56),which were higher than that in the control group (31.50 (13.00,54.75) ng/L,(81.10 ± 15.75)).LVEF in patients with AMI (57.72 ± 9.04) ％,lower than that of the control group ((64.45 ± 6.31) ％),and there were statistically significant difference among the three groups (Z =44.111,P ＜ 0.001 ; F =172.366,18.176,P ＜0.01).There was positive correlation between serum NT-pro BNP levels and GRACE score(r =0.451,P ＜ 0.001),and negative correlation was seen between serum NT-pro BNP and LVEF (r =-0.294,P ＜ 0.001)Conclusion NT-pro BNP level increases and LVEP decreases in patients with ACS and they are related to GRACE score as well as associated with the degree of risk in patients with ACS.
