Relationship between monocyte chemoattractant protein-1 gene polymorphism and susceptibility of epithelial ovarian cancer

VernacularTitle:MCP-1基因多态性与卵巢上皮癌易感性的关系研究
Author: Yang RUAN ; Ke TAO ; Ran ZHANG ; Keqiang ZHANG ; Huijun YANG ; Qixing LI
Publication Type:Journal Article
Keywords: Chemokine CCL2/genetics; Polymorphism,genetic; Polymorphism,restriction fragment length; Polymerase chain reaction; Ovarian neoplasms/genetics; Case-control studies
From: Journal of Chinese Physician 2014;16(10):1342-1345
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between monocyte chemoattractant protein-1 (MCP-1) A-2518G single nucleotide polymorphism (SNPs) and susceptibility of epithelial ovarian cancer(EOC) in Chinese Han population of Hunan region.Methods MCP-1 A-2518G SNPs of the EOC were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 92 patients with EOC and 38 healthy women as control.Results MCP-1 A-2518G SNPs had AA,AG,and GG genotypes in cancer and control groups.The frequencies of AA,AG,and GG genotypes were not significantly different between cancer and control groups (AA:17.40％ and 15.79％ ; AG:44.56％ and 52.63％ ; and GG:38.04％ and 31.58％ ; P ＞0.05).Multivariate logistic regression analysis showed that there was no significant correlation between MCP-1 A-2518G polymorphism and EOC (P ＞0.05).Conclusions This present study suggested that MCP-1 A-2518G polymorphism should not be related to susceptibility of EOC in the Chinese Han population of Hunan region.