Expression of miR-185 in breast cancer and its clinical significance
10.3760/cma.j.issn.1008-1372.2014.09.002
- VernacularTitle:miR-185在乳腺癌组织中的表达及其临床意义
- Author:
Bo CHEN
;
Peng LIU
;
Lu YANG
;
Xiaoping LIU
;
Hailin TANG
;
Xiaoming XIE
;
Weidong WEI
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Breast neoplasms/pathology;
Breast neoplasms/genetics;
In situ hybridization;
Neoplasm recurrence,local;
Neoplasm metastasis;
Neoplasm staging;
Prognosis
- From:
Journal of Chinese Physician
2014;16(9):1156-1158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of miR-185 in breast cancer and its clinical significance.Methods miR-185 expression was detected in 132 cases of breast cancer and 51 cases of benign breast lesions.The correlations of miR-185 ex pression with the clinicopathologic characteristics,overall survival,and disease-free survival of breast cancer patients were analyzed.Results miR-185 was down-regulated in the breast cancer tissues relative to control tissues.The down expression levels of miR-185 cases were found to be significantly associated with tumor node metastasis (TNM) stage,local relapse,and distant metastasis (P ＜ 0.05).Conclusions miR-185 was associated with carcinogenesis,progression,and prognosis of breast cancer and it might be used as a potential target of therapy and a biomarker of diagnosis and prognosis of breast cancer in the future.
