The effect of ω-3 fatty acid supplementation in parenteral nutrition on the outcome of patients with sepsis:a systematic review and Meta-analysis
10.3760/cma.j.issn.2095-4352.2014.03.004
- VernacularTitle:肠外营养添加ω-3多不饱和脂肪酸对脓毒症患者预后的影响:系统文献回顾与Meta分析
- Author:
Yanping MO
;
Xiaolan HU
;
Lili CHANG
;
Penglin MA
- Publication Type:Journal Article
- Keywords:
Sepsis;
Systemic inflammatory response syndrome;
ω-3 polyunsaturated fatty acids;
Randomized controlled trial;
Meta-analysis
- From:Chinese Critical Care Medicine
2014;26(3):142-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether the supplementation of ω-3 polyunsaturated fatty acids in parenteral nutrition (PN) confers treatment benefits to outcomes of septic patients.Methods The databases of MEDLINE,EMBASE,Cochrane central register of controlled trials,the CNKI and the Wanfang biomedicine were searched to identify prospective randomized controlled trials (RCTs) which compared the ω-3 polyunsaturated fatty acids supplemented with the standard PN on outcomes of adult patients with sepsis from January 1996 to June 2013.The methodological quality of the included studies was evaluated,and the Cochrane Collaboration RevMan 5.0 was used for data analysis.Results A total of 12 studies enrolling 721 patients were included.Significant reduction in 28-day mortality [relative risk (RR) 0.77,95％ confidence interval (95％CI) 0.59 to 0.99,P=0.04],short intensive care unit [ICU,weighted mean difference (WMD)=-3.10,95％CI-5.98 to-0.21,P=0.04] and hospital length of stay (WMD =-3.12,95％CI-4.65 to-1.60,P＜0.000 1) were observed in patients receiving ω-3 polyunsaturated fatty acids supplemented PN.There was no differences in days of mechanical ventilation between patients with or without adding ω-3 polyunsaturated fatty acids in PN (WMD =1.33,95％ CI-5.09 to 7.75,P=0.69).Conclusions Meta-analysis results demonstrated that PN supplemented with ω-3 polyunsaturated fatty acids was beneficial in improving the outcomes of patients with sepsis.However,this conclusion must be interpreted with caution due to the low quality of the enrolled trials.
