Research progress of relationship between protein tyrosine phosphatase 1B and hematologic neoplasms
10.3760/cma.j.issn.1009-9921.2015.06.018
- VernacularTitle:蛋白酪氨酸磷酸酶1B与血液系统肿瘤关系研究进展
- Author:
Bing LI
;
Lili ZHOU
;
Jianfei FU
- Publication Type:Journal Article
- Keywords:
Protein tyrosine phosphatase-1B;
Oncogenesis;
Hematologic neoplasms
- From:
Journal of Leukemia & Lymphoma
2015;24(6):376-379
- CountryChina
- Language:Chinese
-
Abstract:
Tyrosine phosphorylation is a key post-translational mechanism that regulates cellular processes and maintains homeostasis.Aberrant changes in tyrosine phosphorylation are often associated with disease states such as metabolicdisorders,cancer and cardiovascular disease.Protein tyrosine phosphatases (PTPs) are the enzyme family that regulates protein phosphorylation level of tyrosine residues in the cellular processes and signaling ways.So far,scientists have discovered 112 kinds of human PTPs.Among them,PTP1B is widely and clearly studied.Recently,as an enzyme that play a role in oncogenesis,PTP1B has been wildey studied by scientists.Here,we highlight the relationship between protein tyrosine phosphatase 1B and hematologic neoplasms.
