Large granular lymphocyte leukemia: three cases report and review of the literature
10.3760/cma.j.issn.1009-9921.2015.05.006
- VernacularTitle:大颗粒淋巴细胞白血病三例并文献复习
- Author:
Hong ZHAO
;
Chengcheng ZHENG
;
Wanling SUN
;
Wuhan HUI
;
Xuejing SUN
;
Li SU
;
Suigui WAN
- Publication Type:Journal Article
- Keywords:
Leukemia,lymphocytic,large granular;
Manifestation;
Immunophenotype;
Therapy
- From:
Journal of Leukemia & Lymphoma
2015;24(5):278-281
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and methods of diagnosis and treatment of granular lymphocytic leukemia (LGLL).Methods Clinical data of 3 patients with LGLL were retrospectively analyzed and relevant literature was reviewed.Results 3 patients were all onset with lymphocytosis,whose conditions progressed slowly.The diagnosis of 2 patients was T-LGLL with immunological characteristics of CD3+ CD4 CD8+ CD56-CD57+.The other patient' s diagnosis was NK-LGLL,whose immunological characteristic was CD3-CD4-CD8-CD56+ CD57-.Two of them didn' t need any treatment.One of them was treated with cyclosporine because of agranulocytosis and recurrent infection.Conclusions LGLL is a group of heterogeneous diseases,which clinical characteristic and prognosis are different.Flow cytometric immunopheotype,TCR Vβ analysis and TCR gene rearrangement are helpful to diagnosis.
