Treatment mechanism of arsenic-containing traditional Chinese medicine on myelodysplastic syndromes
10.3760/cma.j.issn.1009-9921.2015.04.007
- VernacularTitle:含砷中药治疗骨髓增生异常综合征的机制
- Author:
Rou MA
- Publication Type:Journal Article
- Keywords:
Myelodysplastic syndromes;
Arsenic Chinese medcine;
Methylation
- From:
Journal of Leukemia & Lymphoma
2015;24(4):214-216
- CountryChina
- Language:Chinese
-
Abstract:
This is a progress report on myelodysplastic syndromes (MDS) treatment with Chinese medicine containing arsenic in clinic and DNA methylation.Thousands of patients with MDS have been treated by Chinese medicine containing arsenic and 80 ％ total effective rate was got.A few of patients had discontinued the treatment more than one year and all of their blood indicators were normal level.Abnormal methylation in MDS appeared not only obvious hypermethylation but also hypomethylation of some genes.Our research revealed that the mechanism of Chinese medicine containing arsenic on MDS was a two-way regulation of DNA with main mechanism of demethylating and part mechanism of methylating.
